复习和改进组合数据转换:一个新的框架,结合比例转换和对比度转换
Yiqian Zhang1,2, Jonas Schluter3, Lijun Zhang1
1Department of Population and Quantitative Health Sciences, Case Western Reserve University, 2109 Adelbert Rd, Cleveland, 44106, OH, USA.
Computational and structural biotechnology journal
|December 3, 2024
概括
这项研究解决了人类微生物组数据的统计挑战,例如零通货膨胀. 它引入了数据转换的新框架,增强了微生物组研究的分析.
科学领域:
- 微生物组研究的研究.
- 统计分析 统计分析
- 生物信息学是一种生物信息学.
背景情况:
- 人类微生物组对健康和疾病至关重要,但其数据带来了统计挑战,如不同测序深度,组成性和零通货膨胀.
- 现有的数据转换方法 (例如,缩放,CLR,ALR) 可以引入偏差并产生不一致的结果.
- 解决这些挑战对于准确的微生物组数据分析至关重要.
研究的目的:
- 系统地审查微生物组数据的组成数据转换技术.
- 开发一个新的框架,用于创建新的数据转换.
- 为零膨胀微生物组数据引入和评估新的转换 (CAC,AAC).
主要方法:
- 对现有的组成数据转换方法进行系统审查.
- 开发一个新的框架,结合比例转换和对比变换.
- 引入了新的转换方法:集中弧线对比 (CAC) 和添加弧线对比 (AAC).
- 在不同水平的零通胀场景中评估转型绩效.
主要成果:
- 拟议的框架涵盖了现有的方法,如增量日志比率 (ALR) 和中心日志比率 (CLR).
- 在高零通胀情景中,CAC和AAC转换显示了更好的表现.
- 当零值不那么普遍时,ALR和CLR转换更有效.
- 该研究提供了不同转换技术的全面比较.
结论:
- 开发的框架为微生物组数据转换提供了灵活的方法.
- 新的CAC和AAC转换改进了零膨胀微生物群数据集的分析.
- 这些发现引导研究人员选择适合微生物组数据分析的转换方法,改善分析结果.
更多相关视频
相关概念视频
Sample Proportion and Population Proportion
5.2K
Collecting samples or responses from an entire population takes significant time and effort, so a researcher collects responses from only a sample of that population. Suppose a study needs to collect information about a specific mobile application. After sample collection, the researcher analyzes the data and discovers that most individuals in the sample use that specific mobile application. The sample proportion measures the number of individuals in a sample who either use or don't use the...
5.2K
Forced Transdifferentiation
1.9K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
Artificial...
1.9K
Transformation of Plane Strain
156
When analyzing elongated structures like bars subjected to uniformly distributed loads, it is essential to understand the transformation of plane strain when coordinate axes are rotated. This transformation helps to assess how material deformation characteristics vary with orientation, which is crucial in materials science and structural engineering.
Under plane strain conditions, typical for members where one dimension significantly exceeds the others, deformations and resultant strains are...
Under plane strain conditions, typical for members where one dimension significantly exceeds the others, deformations and resultant strains are...
156
Conversion of Units
22.1K
Sometimes, there is a need to convert from one unit to another one. For instance, reading a cookbook in which quantities are expressed in units of liters or ounces may require conversion of quantities to cups. Or, when looking up directions on how to get to a location, we may be interested to know how many miles we are going to walk. In this case, we would have to convert units of feet or meters to miles.
The first step in the unit conversion is to list the given units and the units required...
The first step in the unit conversion is to list the given units and the units required...
22.1K
Source Transformation
3.7K
Source transformation is a fundamental technique employed in circuit analysis, offering a valuable tool for simplifying complex electrical circuits. This technique involves the replacement of either a voltage source in series with a resistor by a current source in parallel with a resistor, or vice versa. The key concept here is that when the original sources are deactivated (turned off), the equivalent resistance at the circuit's end terminals remains the same.
It is essential to note that when...
It is essential to note that when...
3.7K
Difference Equation Solution using z-Transform
250
The z-transform is a powerful tool for analyzing practical discrete-time systems, often represented by linear difference equations. Solving a higher-order difference equation requires knowledge of the input signal and the initial conditions up to one term less than the order of the equation.
The z-transform facilitates handling delayed signals by shifting the signal in the z-domain, which corresponds to delaying the signal in the time domain, and advancing signals by similarly shifting in the...
The z-transform facilitates handling delayed signals by shifting the signal in the z-domain, which corresponds to delaying the signal in the time domain, and advancing signals by similarly shifting in the...
250


