相关实验视频
Updated: Jun 6, 2025
04:33
Methods for Detecting Cough and Airway Inflammation in Mice
Published on: August 2, 2024
559
探索临床上对咳发作有意义的定义
Kimberley J Holt1,2, Rachel J Dockry1,2, Kevin McGuinness1,2
1Division of Infection, Immunity and Respiratory Medicine, University of Manchester and Manchester Academic Health Science Centre, Manchester, UK.
ERJ open research
|December 3, 2024
概括
使用短时间间隔 (≤3秒) 定义咳发作并排除单次咳,可以改善耐性慢性咳 (RCC) 严重性的分析. 这种方法更好地捕捉了咳聚类及其对患者的影响.
科学领域:
- 肺病学和呼吸系统医学
- 生物声音的声学分析
- 临床试验方法论 临床试验方法论
背景情况:
- 目前临床试验中的咳频率测量通常使用每小时咳的声音,忽略了咳聚集成发作.
- 咳发作显著影响感知严重程度和并发症,但没有标准化的定义.
- 耐久性慢性咳 (RCC) 患者数据对于了解咳动态至关重要.
研究的目的:
- 调查不同定义的咳发作如何影响耐火性慢性咳 (RCC) 中产生的参数.
- 探索不同咳发作定义,报告的咳严重程度和人口统计学因素 (年龄,性别) 之间的关系.
- 在临床研究中建立一种更精确的分析咳发作方法.
主要方法:
- 对91名RCC患者咳严重程度的24小时声学录音和视觉模拟尺度的分析.
- 开发一种定制的算法,以根据爆炸性咳声音之间的间隔 (≤0.5秒至≤10秒的增量) 来定义咳发作.
- 计算参数,包括发作次数,中位数/最大发作时间和总发作时间.
主要成果:
- 咳间隔>3秒对咳发作参数的影响最小.
- 咳严重程度和发作参数之间的相关性很弱,但当单次咳被排除在外时,它得到了加强.
- 没有咳的时间和咳的总时间对咳的严重性比平均咳时间更有影响.
结论:
- 支持使用≤3秒的咳间隔的咳发作定义.
- 从分析中排除单个咳,可以更有意义地了解咳症状的特征.
- 这些精细的定义增强了对耐性慢性咳患者咳严重程度的理解.
相关概念视频
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
01:20COPD: Pathogenesis and Clinical Features
232
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
232
01:22Chronic Obstructive Pulmonary Disease
1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
01:26Respiratory Volumes and Capacities I
934
Assessing the respiratory rate and rhythm for a complete minute is crucial for evaluating the breathing pattern. Even a minor increase in the patient's average respiratory rate, by as little as three to five breaths per minute, is an early and vital indicator of respiratory distress. Patients with a respiratory rate exceeding twenty-four breaths per minute require close monitoring to determine the physiological alterations. This careful observation is essential for prompt recognition and...
934