胸膜上皮瘤和骨髓灰质炎的手术治疗
Gizem Özçıbık Işık1, Akif Turna1
1Department of Thoracic Surgery, Istanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty, Istanbul, Türkiye.
Frontiers in surgery
|December 3, 2024
概括
甲状腺上皮瘤,包括甲状腺瘤和甲状腺癌,很少见,并且经常与像骨髓灰质炎这样的自身免疫性疾病有关. 治疗取决于切除能力,手术是早期阶段的关键,化学治疗是晚期疾病的关键.
科学领域:
- 在瘤学瘤学.
- 胸部外科手术 胸部外科手术
- 自体免疫学 自体免疫学
背景情况:
- 胸腺上皮瘤 (TETs) 起源于胸腺上皮细胞,通常在第五至第六十年诊断出来.
- 亚型包括胸腺瘤 (75-80%) 和胸腺癌 (15-20%),具有不同的预后和生存率.
- TETs与神经瘤性自身免疫性疾病有关,特别是严重肌痛性肌痛症 (MG).
研究的目的:
- 提供关于胸膜上皮瘤的全面概述,包括其流行病学,亚型,临床表现,分期和治疗.
- 突出TETs与自身免疫性疾病之间的关联,特别是严重骨髓灰质炎.
- 讨论当前的治疗策略,包括手术干预和全身治疗.
主要方法:
- 对胸膜上皮瘤的流行病学数据和疾病特征的审查.
- 阶段化系统的分析 (Masaoka-Koga,TNM第八版).
- 基于切除能力和疾病阶段的治疗算法的摘要,包括手术和瘤方法.
主要成果:
- 胸腺瘤生长缓慢且局限,而胸腺癌则具有具有转移潜力的侵略性.
- 胸腺瘤的5年生存率为78%,胸腺癌为30%.
- 骨髓灰质炎大约影响了10%的胸腺瘤患者;诊断包括抗体检测和EMG,治疗选择是乳腺切除术.
结论:
- 对TETs的治疗取决于阶段,优先考虑可切除的早期疾病的扩展性胸膜切除术.
- 化疗是高级或转移性TETs的主要治疗方式,随后通常是手术和放射治疗.
- 最少侵入性手术技术 (VATS,RATS) 的结果与切除TET的胸腔切除术相似.
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