在各种临床样本中的肠球菌种的流行率及其抗菌素敏感性模式
Manasi Mahajan1, Ravindra Shinde1, Geeta S Karande1
1Department of Microbiology, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Cureus
|December 3, 2024
概括
肠杆菌,常见的肠道细菌,越来越多地导致严重的感染. 这项研究发现,泰科普拉宁对这些多抗药性病原体有效,突出显示印度需要更好的监测和感染控制.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 临床研究 临床研究
背景情况:
- 格拉姆阳性肠球菌,通常是肠道共生菌,正在成为引起严重感染的重要病原体,如脑膜炎,细菌病和内心炎,特别是在免疫受损的个体中.
- 多种药物耐药性的流行,由vanA,vanB和vanC等基因驱动,在诸如Enterococcus faecalis和Enterococcus faecium等物种中,是一个日益严重的全球健康问题.
- 需要加强监测,感染控制和抗菌药物管理,以对抗这些日益危险的感染,印度对肠球菌遗传特征存在特定的研究缺口.
研究的目的:
- 从印度的各种临床样本中确定*Enterococcus*分离物的频率.
- 为了研究这些*Enterococcus*分离的抗生素耐药性模式.
- 为改善感染控制和治疗肠球菌感染的治疗策略提供数据.
主要方法:
- 根据先前的研究,对114个样本进行了横截面观察性研究,样本大小为114.
- 从临床样本中分离出肠球菌,包括尿液,血液,唾液,伤口抹布和无菌体液.
- 鉴定涉及格拉姆染色,文化特征和生物化学测试 (胆结素水解,盐耐受性). 使用Kirby-Bauer光盘扩散方法评估了抗生素敏感性.
主要成果:
- 总共有120个Enterococcus*分离物被确定,主要是Enterococcus faecium*和Enterococcus faecalis*.
- 大多数分离物 (69.16%) 来自尿样,其次是血液 (12.5%).
- 在分离物中观察到最高的铁素敏感性 (79.16%). 大多数孤立 (96.66%) 来自住院机构,特别是重症监护室 (CCU) 和重症监护室 (ICU).
结论:
- 在临床环境中, *Enterococcus* 种类是重要的病原体,在样本类型中分布不同.
- 泰科普拉宁表现出对所研究的 *Enterococcus* 隔离物的最高敏感性.
- 了解 *Enterococcus* 的流行率和抗菌素敏感性对于有效的感染控制,抗生素管理和印度公共卫生政策制定至关重要.
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