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从Ophiopogon japonicus中提取,净化,结构特征,生物活性,修饰和多糖的结构-活性关系:一篇综述
Yiqiang Zhang1, Bo Chen2,3, Hua Zhang4
1Department of Respiratory and Critical Medicine, Jingmen Hospital of Traditional Chinese Medicine, Jingmen, China.
Frontiers in nutrition
|December 3, 2024
概括
奥菲奥波日方菌多糖 (Ophiopogon japonicus polysaccharides,简称OJPs) 是传统中医药中的生物活性化合物,具有多种健康益处. 结构修改增强了它们的药理活性和生物可用性,用于医疗和食品应用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
- 传统中国医药 传统中国医药
背景情况:
- 日本 (Ophiopogon japonicus (Thunb.)) 是一种类植物. 凯尔·加尔. 卡尔·加尔 是一种长期存在的传统中医药.
- 奥菲奥波冈日本的多糖 (Ophiopogon japonicus polysaccharides,简称OJPs) 是从这种草本中提取的关键生物活性大分子.
- OJPs主要由葡萄糖和果糖组成,分子重量在2.48至325kDa之间.
研究的目的:
- 系统地审查OJPs的提取,净化和结构特征.
- 分析OJPs的生物功能,分子机制和结构-活动关系.
- 探索结构修改如何影响OJP活动和生物可用性.
主要方法:
- 对OJP提取和净化研究的文献综述.
- 对OJP生物活动和机制的研究分析.
- 审查涉及对 OJP 的结构修改的研究.
主要成果:
- OJPs表现出显著的低血糖,心脏保护,免疫调节,抗肥胖和脏保护活动.
- 结构特征揭示了它们复杂的多糖体性质.
- 像脂质体,硫化和聚乙烯糖醇结合等修改增强了OJP的药理作用.
结论:
- 本综述提供了对Ophiopogon japonicus.的OJPs的全面了解.
- OJPs在医学和健康食品中具有广泛的治疗潜力.
- 结构修改策略对于优化OJP的有效性和应用至关重要.
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