结合德克斯梅托米丁的埃斯凯特胺对接受腰椎手术的老年患者早期术后认知功能的影响:双盲随机对照临床试验
Qing-Yu Tao1, Dong Liu1, Shi-Jie Wang2
1Department of Anaesthesiology, The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), Hefei, Anhui, 230061, People's Republic of China.
Drug design, development and therapy
|December 3, 2024
概括
艾斯基他胺和德克斯梅德托米丁的组合可显著降低腰部手术后老年患者的术后认知功能障碍 (POCD). 这种方法还降低了与脑损伤相关的关键生物标志物在术后第一天.
科学领域:
- 麻醉学 麻醉学
- 神经科学是一个神经科学.
- 老年医学 老年医学
背景情况:
- 术后认知功能障碍 (POCD) 影响高达25.6%的非心脏手术后老年患者.
- 波多野结衣症具有很大的风险,特别是在接受腰椎手术等重大手术的老年人中.
研究的目的:
- 评价埃斯基坦胺和德克斯梅德托米丁在预防腰椎手术的老年患者中预防POCD的联合疗效.
- 通过检查特定的生物标志物和临床结果来调查潜在机制.
主要方法:
- 一项随机对照试验,涉及162名接受腰椎手术的老年患者.
- 患者被分为三个组:乙胺加上德克斯梅德托米丁 (ED),单独乙胺 (E) 或单独德克斯梅德托米丁 (D).
- 主要结局是术后第一天的POCD发病率;次要结局包括POCD在第三天,血清生物标志物 (NSE,S100β),疼痛评分 (VAS) 和不良事件.
主要成果:
- 与E组相比,ED组在术后第一天的POCD发病率明显较低 (P=0.017).
- 与E和D组相比,ED组的神经元特异性酶 (NSE) 和S100β的血清水平显著降低 (P<0.05).
结论:
- 乙胺和德克斯梅德托米丁的组合有效地降低了经腰椎手术的老年患者中POCD的发生率.
- 这种组合可能提供神经保护性益处,如NSE和S100β的水平降低所示.
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