阿斯特拉加勒斯的多糖类通过调节肠道微生物群和血清代谢学来缓解喘
Jie Zhang1, Ming Guan2, Suling Wu1
1Department of Pediatrics, Hangzhou Children's Hospital, Hangzhou, Zhejiang 310014, P.R. China.
Biomedical reports
|December 3, 2024
概括
阿斯特拉加勒斯多糖 (APS) 通过恢复肠道微生物群平衡和纠正血清代谢物异常,改善了喘小鼠的呼吸道炎症. 这项研究强调了APS作为喘管理的潜在治疗剂.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 喘是一种慢性呼吸道疾病,其特点是气道炎症和过度反应.
- 肠道微生物群失生症越来越多地被认为是导致喘发病的一个因素.
- 阿斯特拉加卢斯多糖 (Astragalus polysaccharide,简称APS) 是一种具有潜在免疫调节功能的天然化合物.
研究的目的:
- 在喘小鼠模型中,研究阿斯特拉加卢斯多糖 (Astragalus polysaccharide,APS) 对肠道微生物群和血清代谢物的影响.
- 评估APS在改善呼吸道炎症和喘小鼠过敏反应方面的治疗潜力.
主要方法:
- 在BALB/c小鼠中建立卵泡胺 (OVA) 诱导的喘模型.
- 在喘小鼠中给予不同剂量的APS和德克萨米他.
- 评估气道过敏反应 (AHR) 和肺炎透.
- 使用16S rRNA测序对肠道微生物群组成的分析.
- 使用超高性能液体染色学-并联质谱法 (UPLC-MS/MS) 进行血清代谢物的分析.
主要成果:
- 在喘小鼠中,APS治疗显著降低了呼吸道炎症和氨基透.
- 服用APS可以纠正肠道微生物的不平衡,降低Firmicutes/Bacteroidetes的比率.
- 代谢分析显示,在APS治疗后,不和脂肪酸生物合成,氨酸生物合成和pyrimidine代谢途径发生了显著的改变.
- 在改善喘症状方面,APS的疗效与德克萨米他相当.
结论:
- 阿斯特拉加卢斯多糖 (APS) 有效调节喘小鼠的肠道微生物群和血清代谢物.
- APS在改善呼吸道炎症和喘中的高反应性方面具有治疗潜力.
- 这些发现表明,APS可能是治疗喘的有希望的天然治疗剂.
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