科普蒂迪斯瘤对胃肠道系统的作用,在与基于肠道微生物群和短链脂肪酸的葡萄酒进行加工之前和之后
Rui Tian1, Wen-Xiao Wang2, Ya-Ya Bai1
1Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, State Key Laboratory of Research and Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Traditional Chinese Medicine Processing Technology Heritage Base, Shaanxi University of Chinese Medicine, Xi'an, China.
Frontiers in pharmacology
|December 3, 2024
概括
葡萄酒加工Coptis deltoidea (CD) 通过改变肠道微生物群和炎症反应来减少胃肠道损伤. 与未经加工的CD相比,加工CD (PCD) 对肠道健康具有较轻的影响,支持其传统的使用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 传统中国医药 传统中国医药
背景情况:
- 科普蒂斯deltoidea (CD) 用于热毒素条件,但可能导致胃肠道损伤.
- 葡萄酒加工的CD旨在减轻苦味,寒冷的特性,并减少胃肠道的副作用.
- 了解加工和未加工CD的差异影响对于优化其治疗应用至关重要.
研究的目的:
- 评估Coptis deltoidea (CD) 和葡萄酒加工CD (PCD) 对胃肠道系统的不同影响.
- 调查由CD和PCD影响的潜在机制,包括肠道微生物群和炎症途径.
- 为CD的传统葡萄酒加工实践提供科学证据.
主要方法:
- 超高性能液态染色体质谱仪 (UPLC-MS) 用于CD和PCD的成分分析.
- 在接受CD和PCD治疗的小鼠中,胃肠道病理评估,血清炎症因子和NF-κB p65蛋白质的确定.
- 便短链脂肪酸 (SCFA) 分析和肠道微生物群 (GM) 通过16SrRNA测序进行分析.
主要成果:
- CD的使用减少了体重和食物摄入量,改变了便中的水含量和肠道过渡时间,并减少了SCFA.
- 疾病诱导胃肠道损伤,增加NF-κB p65表达,以及炎症因子升高,对小肠和结肠的影响更为明显.
- 与CD相比,PCD表现出较弱的胃肠道损伤和炎症反应,肠道微生物群的调节障碍较轻.
结论:
- 科普蒂斯deltoidea (CD) 可以诱导胃肠道损伤,可能与肠道微生物群疾病,改变的SCFA,NF-κB激活和炎症有关.
- CD (PCD) 的葡萄酒加工减轻了这些不良影响,可能是由于成分配置的差异.
- 这项研究支持了葡萄酒加工缓解与胃中CD相关的"苦冷伤害"的机制.
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