核心实验室与中心报告的本地和生物假体大动脉的心声评估

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Bart J J Velders¹, Michiel D Vriesendorp¹, Neil J Weissman²

¹Cardiothoracic Surgery, Leiden University Medical Centre, Leiden, the Netherlands.

Echocardiography (Mount Kisco, N.Y.)

|December 3, 2024

概括

大动脉的心声评估显示多普勒测量高度一致,但对LVOT直径的一致性较低. 这影响了在没有核心实验室评估的情况下解释门性能.

科学领域:

心脏病学心脏病学
心声回声扫描 (Echocardiography) 是一种心声回声扫描.
假肢的评估假肢的评估

背景情况:

核心实验室和原生和生物假体大动脉临床中心之间的回声心脏学评估的定量差异尚未得到充分理解.
这项研究解决了对这些临床相关差异的洞察的需求.

研究的目的:

在独立的核心实验室和临床场所之间比较原生和生物假体大动脉的回声心脏学评估.
量化各种心声回声学参数的测量差异和一致性.

主要方法:

利用了PERIGON关键试验 (NCT02088554) 的数据,该试验涉及接受大动脉置换手术的患者.
在临床中心分析的连续回声心电图与独立回声心电图核心实验室 (ECL) 进行的盲目再分析进行了比较.
使用平均差异,类内相关系数 (ICC) 和科恩的kappa进行分类来量化差异.

主要成果:

对于多普勒衍生参数 (如峰值大动脉喷流速度和平均压力梯度) 发现了高度一致 (ICCs ~0.90).
对于涉及左心室外流管 (LVOT) 直径测量的参数,观察到较低的一致性.
对于分类大动脉反 (AR),准膜泄漏 (PVL) 和假肢患者不匹配 (PPM) 的协议有所不同,PPM和PVL的一致性较低.

结论:

核心实验室和临床中心回声心脏学之间存在实质性的协议,用于对大动脉的连续波多普勒测量.
对于需要LVOT直径的测量,差异更为明显,影响门性能的解释.
这些发现对于解释大动脉功能数据至关重要,特别是在缺乏中央核心实验室监督的研究中.

关键词:

生物假体大动脉门核心实验室核心实验室超声心电图 (Echocardiography) 是一种心声回声仪.观察者之间的可变性.原生主动脉门原生主动脉门

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