在心力衰竭患者中,晚期肺癌炎症指数的预后值:综合分析
Wentao Chen1, Guihua Zhang1, Qiao Lei1
1National Key Laboratory for Innovation and Transformation of Luobing Theory; The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
ESC heart failure
|December 3, 2024
概括
晚期肺癌炎症指数 (ALI) 与心力衰竭 (HF) 患者的死亡率和心脏变化有关. 更高的ALI水平表明HF患者的预后更好,表明其预后价值.
科学领域:
- 心脏病学和心血管研究
- 炎症和免疫学 炎症和免疫学
- 营养生物标志物 营养生物标志物
背景情况:
- 心力衰竭 (HF) 的预后受到炎症和营养状况的重大影响.
- 晚期肺癌炎症指数 (ALI) 整合了炎症和营养标志物.
- 在HF患者中,ALI的预后效用尚未完全阐明.
研究的目的:
- 在心力衰竭 (HF) 患者中调查晚期肺癌炎症指数 (ALI) 的预后价值.
- 评估ALI与HF患者的长期死亡率 (因任何原因和心血管) 之间的关联.
- 探索ALI和心脏结构变化之间的关系,包括左心室逆向重塑 (LVRR) 和细胞外体积 (ECV).
主要方法:
- 研究1使用了来自NHANES数据库 (1999-2018) 的1359名高温患者的数据.
- 卡普兰-梅尔分析,考克斯回归,时间依赖的ROC曲线和受限立方线 (RCS) 被用于评估死亡风险.
- 第二项研究分析了接受心脏MRI的79名HF患者的数据,使用逻辑回归和斯皮尔曼相关性来评估ALI与LVRR和ECV的关联.
主要成果:
- 在多变量调整后,高高的ALI水平与所有原因和心血管死亡风险的降低显著相关 (研究1).
- 在ALI和死亡率之间观察到线性负相关性,时间依赖的ROC曲线表明ALI在3,5年和10年的死亡率的预测值.
- 较高的ALI水平与LVRR相关,并且在HF患者中与ECV呈负相关性 (研究2).
结论:
- 晚期肺癌炎症指数 (ALI) 作为心力衰竭 (HF) 患者的宝贵预后指标.
- ALI独立地与所有原因和心血管死亡率的风险降低有关.
- ALI与有利的心脏结构变化相关,包括左心室逆向重塑和较低的细胞外体积.
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