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Updated: May 5, 2026

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
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Published on: September 20, 2011

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提高PARP抑制剂的有效性,使用纳米颗粒进行降解反应,封装NADP

Hao Chen1, Fan Tan1, Yukui Zhang1,2

  • 1Key Laboratory of Molecular Medicine and Biological Diagnosis and Treatment (Ministry of Industry and Information Technology), School of Life Science, Beijing Institute of Technology, Beijing 100081, China. xiebingteng@bit.edu.cn.

Journal of materials chemistry. B
|December 3, 2024
PubMed
概括

这项研究开发了提供NADP+的纳米粒子,以使瘤对PARP抑制剂 (如olaparib) 敏感. 这种组合疗法通过增强DNA修复抑制来有效抑制瘤细胞的生长.

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Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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