大动脉脉冲波速的节奏变化:对大动脉硬度测量的影响
Alessandro Giudici1,2, Andrea Grillo3, Filippo Scalise4
1Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM).
Journal of hypertension
|December 3, 2024
概括
大动脉脉冲波速度 (aPWV) 的节拍变化是可以管理的. 平均至少十次心跳减少了可变性,确保可靠的aPWV测量用于心血管风险评估.
科学领域:
- 心血管生理学心血管生理学
- 生物医学工程 生物医学工程
- 临床测量 临床测量
背景情况:
- 大动脉脉冲波速度 (aPWV) 是心血管风险的关键预测指标,也是评估大动脉硬性的标准.
- 侵入性aPWV测量是验证非侵入性设备的参考标准.
- 在aPWV中,节奏对节奏的变化源于血液动力学波动和数据处理挑战.
研究的目的:
- 量化侵袭性aPWV的节奏对节奏的变化.
- 评估不同采集协议和数据处理方法对aPWV变异性的影响.
- 确定这种变异性对在临床研究和设备验证中使用aPWV的影响.
主要方法:
- 从84名患者中收集了侵入性压力数据,使用同时升起的大动脉和阴道导管采集.
- 顺序采集协议与同时采集协议进行了比较,以评估可变性.
- 分析了三种不同的压力波形脚识别方法,以评估加工效应.
- 估计了平均连续心跳对aPWV变异性的影响.
主要成果:
- 同时获得的侵入性aPWV表现出5%的节拍对节拍标准偏差 (SD).
- 与同时获取相比,顺序获取协议增加了aPWV的变化.
- 连续10次心跳的平均值显著降低了可变性,在两种获取方法中产生了可比结果 (2-3% SD).
结论:
- aPWV的内在节拍变异性在临床上是可以控制的.
- 在至少十次心跳中平均 aPWV 测量确保可靠和一致的结果.
- 这一发现支持在临床应用和设备验证研究中对aPWV的强有力的使用.
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