心脑轴中的动脉化和随着时间的推移的认知表现
Anna M Streiber1,2, Tim C van den Beukel2,3, Ilse Vom Hofe2
1Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 3, 2024
概括
动脉化是一种动脉硬化的迹象,与更快的认知衰退有关,特别是当它影响到靠近大脑的动脉时. 这种血管损伤会影响所有领域的思维.
科学领域:
- 神经科学是一个神经科学.
- 心血管健康 心血管健康
- 衰老研究研究 衰老研究
背景情况:
- 截面研究表明动脉样硬化和认知障碍之间存在联系.
- 关于动脉样硬化和认知轨迹的纵向数据有限.
- 随着时间的推移,研究心脑轴与认知表现的关系至关重要.
研究的目的:
- 检查心脑轴动脉样硬化与认知性能轨迹之间的关联.
- 为了确定动脉化是否预测认知能力的纵向变化.
主要方法:
- 利用了基于人口的鹿特丹研究 (n=2368) 的数据.
- 在五个主要的心脑轴动脉中使用非对比CT评估动脉化.
- 使用混合模型分析了基线化和重复认知测试之间的关系.
主要成果:
- 在多个领域中,较高的动脉化与较差的基线认知表现相关.
- 在内状动脉化和全球认知之间观察到显著的关联.
- 认知功能随着时间的推移表现出更快的下降,特别与内 carotid 动脉化有关 (p ≤ 0.001).
结论:
- 动脉化与各种领域的加速认知衰退有关.
- 靠近大脑的动脉的化,比如内动脉,对认知能力下降有更明显的影响.
- 血液动力学变化和随后的神经血管损伤可能会影响动脉样硬化对认知功能的影响.
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