相关实验视频
Updated: Jun 6, 2025

Intravascular Delivery of Biologics to the Rat Kidney
Published on: September 1, 2016
使用低剂量布普伦诺芬的甲-布普伦诺芬转移:一个开放的,非随机的临床试验
Chris Tremonti1, James Blogg, Nazila Jamshidi
1From the Alcohol and Drug Services St Vincent's Hospital, Sydney, Australia (CT); Sydney Local Health District Drug Health Services, Sydney, Australia (CT, JB, NJ, PH); University of Sydney, Sydney, Australia (CT); Drug Health Services, South Western Sydney Local Health District, Sydney, Australia (RH); Northern Sydney Local Health District, Drug & Alcohol Service, Sydney, Australia (NM); Drug and Alcohol Clinical Services, Hunter New England Local Health District, Newcastle, Australia (CI); South Eastern Sydney Local Health District, Drug and Alcohol Services, Sydney, Australia (RP, NL); UNSW Sydney (RP); Division Addiction Medicine, Central Clinical School; South Eastern Sydney Local Health District, Drug and Alcohol Services, NSW Drug and Alcohol Clinical Research and Improvement Network (DACRIN), Sydney, Australia (LM, NL, PH); NSW Poisons Centre, Sydney, Australia (NB); Edith Collins Centre, Royal Prince Alfred Hospital, Sydney, NSW, Australia (NB, VP, PH); Clinical Pharmacology and Toxicology Research Group, Biomedical Informatics & Digital Health, Sydney Medical School, University of Sydney, Sydney, Australia (NB, VP); NSW Health Speciality of Addiction Medicine, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia (NL); and Faculty of Health and Medicine University of Sydney, Sydney, Australia (NJ, PH).
一项用于将患者从甲转移到布普伦诺芬的新低剂量协议显示,成功率与标准治疗相似. 较高的初始甲剂量与成功转移的可能性降低有关.
科学领域:
- 药物成 药物成 药物
- 药理学 药理学是指药理学的学科.
- 临床试验中的临床试验.
背景情况:
- 阿片类药物使用障碍 (OUD) 治疗通常涉及患者在药物之间进行转换.
- 甲和布普伦诺芬是OUD治疗中常用的药物.
- 优化这些药物之间的传输协议对于患者的护理连续性至关重要.
研究的目的:
- 为了比较一种新型低剂量方案的疗效与从甲转换为布普伦诺芬的患者的标准护理.
- 为了评估患者在转移后一周内继续使用布普伦诺芬的比例.
主要方法:
- 一个非随机的,开放的临床试验在澳大利亚新南威尔士州的8个地点进行.
- 参与者被分配到低剂量布普伦诺芬转移协议或标准护理.
- 主要结局是1周后继续服用布普伦诺芬,使用二进制逻辑回归分析.
主要成果:
- 该研究包括117名参与者,其中101人在低剂量组和16人在标准护理组.
- 持续率相似:低剂量组80%和标准护理组81% (OR = 2.22;P = 0.327).
- 较高的基线甲剂量是较低成功率的显著预测因素 (OR = 0.8每10毫克;P = 0.04).
结论:
- 在低剂量和标准护理转移协议之间没有观察到布普伦诺芬持续时间的显著差异.
- 较高的甲剂量预测成功转移的可能性降低.
- 研究设置 (门诊 vs 住院) 没有影响转移成功.
更多相关视频
04:13Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models
Published on: September 27, 2024
09:54Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
Published on: March 8, 2020
相关概念视频
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Drug Abuse and Addiction: Pharmacological Phenomena
Phase II Reactions: Methylation Reactions
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Opioid Analgesics: Morphine and Other Natural Cogeners
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...