以正念为基础的认知疗法 - - 双相情感障碍患者的常规治疗:一个多中心,随机对照试验
Imke Hanssen1,2, Marloes Huijbers1,2, Eline Regeer3
1Department of Psychiatry, Radboud University Medical Center, Center for Mindfulness, Reinier Postlaan 4, 6526 GC, Nijmegen, the Netherlands.
Psychological medicine
|December 3, 2024
概括
基于正念的认知疗法 (MBCT) 与通常治疗 (TAU) 相比,在双相情感障碍 (BD) 患者中没有显著减少抑郁症状. 然而,MBCT可能有利于中度至重度抑郁症和功能障碍患者.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 心理健康研究 心理健康研究
背景情况:
- 双极性障碍 (BD) 的管理往往需要辅助疗法.
- 基于正念的认知疗法 (MBCT) 显示了BD的潜力,但随机对照试验 (RCT) 的强有力的证据有限.
- 这项研究解决了在BD中严格评估MBCT的需要.
研究的目的:
- 评估MBCT对双相情感障碍 (BD) 患者的常规治疗 (TAU) 的附加值.
- 评估MBCT在干预后长达15个月的疗效.
- 为了确定在BD中治疗结果的潜在调节者.
主要方法:
- 一个多中心,评估者盲目的随机对照试验 (RCT) 涉及144名参与者与BD类型I和II.
- 参与者被随机分配到MBCT+TAU或单独TAU.
- 主要结局是目前的抑郁症状;次要结局包括躁狂,焦虑症状,复发率,反,影响调节,功能和正念技能.
主要成果:
- 在治疗后或随访时,MBCT + TAU在减少抑郁症状方面没有比TAU更高的疗效.
- 在治疗后,MBCT + TAU 显示了正念技能的改善.
- 在随访时,单独TAU在减少焦虑和改善正念和积极心理健康方面更有效;然而,探索性分析表明,MBCT + TAU有利于基线抑郁症和功能障碍较高的参与者.
结论:
- 对于经历中度至重度抑郁症和功能障碍的高度复发性双相情感障碍患者,MBCT可以作为额外的治疗选择.
- 这些发现表明,在BD中,MBCT应采用个性化的方法,针对特定的症状概况.
- 需要进一步的研究来完善MBCT在BD群体中的应用.
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