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Updated: Jun 6, 2025

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
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在衰老过程中,细胞质色素碎片的形成需要TPR

Bethany M Bartlett1, Yatendra Kumar1, Shelagh Boyle1

  • 1MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom.

eLife
|December 3, 2024
PubMed
概括

核孔蛋白TPR在瘤基因诱导衰老过程中对早期NF-κB激活至关重要. 这将异色素蛋白重组与细胞质色素碎片和先天性免疫信号联系起来,驱动与衰老相关的分泌表型 (SASP).

关键词:
细胞生物学 细胞生物学染色体是一种染色体.基因表达的基因表达方式基因组的完整性 基因组的完整性异性染色是一种异性染色.人类 人类 人类 人类 人类 人类 人类这是一种炎症炎症炎症炎症.核边缘地区的核边缘地区在基因上,我们发现了基因上的差异.衰老是一种老化.

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