在haloperidol诱导的老鼠模型中,Bacillus subtilis的神经保护作用,准微生物群-肠-大脑轴
Monalisa Rout1, Durga Madhab Kar1, Debasmita Dubey2
1School of Pharmaceutical Sciences, Siksha 'O' Anusandhan deemed to Be University, Bhubaneswar, India.
Journal of molecular histology
|December 3, 2024
概括
益生菌,特别是细菌细菌,通过改善运动功能和减少神经炎症,在治疗帕金森病方面表现有前途. 这项研究强调了肠-大脑轴作为新帕金森病治疗的关键目标.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 帕金森病 (PD) 越来越多地与肠道微生物组失调有关.
- 益生菌 (PBT) 在PD中的治疗机制,特别是它们通过肠-大脑轴的抗氧化作用,仍未得到充分研究.
研究的目的:
- 为了研究Bacillus subtilis (PBT) 的抗氧化作用和机制,研究了一种由haloperidol诱导的帕金森病大鼠模型.
- 评估PBT与L-DOPA结合在缓解PD症状和潜在病理方面的疗效.
主要方法:
- 使用哈洛佩里多尔 (HAL) 注射建立PD大鼠模型.
- 通过神经行为测试来评估运动功能.
- 测量了α-synuclein聚合,单氨酸氧化酶-B (MAO-B) 活性,多巴胺基神经元完整性,氧化应激标记物 (氨酸,超氧化物转化酶) 和肠道微生物组成.
主要成果:
- 同时服用PBT和L-DOPA可以缓解运动缺陷,保护多巴胺基神经元,并减少HAL治疗的老鼠的α-synuclein积累.
- PBT治疗增加了超氧化物脱酶和多巴胺水平,同时降低了α-synuclein,MAO-B和malondialdehyde.
- PBT调节了肠道微生物群,增加了有益的Bifidobacterium和减少了大肠杆菌,从而减少了肠道微生物失调.
结论:
- 细菌细菌 (PBT) 在帕金森病模型中显示出显著的神经保护和抗氧化作用.
- 通过准肠-大脑轴并恢复微生物平衡,PBT可能是抑制帕金森病进展的有希望的治疗策略.
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