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低频波动的表面振幅的变化初级开角玻璃眼与神经递质分析和视力障碍严重程度的联系

Zihan Chai¹, Bingbing Yang¹, Xiaoxia Qu¹

¹Department of Radiology, Beijing Tongren Hospital, Capital Medical University, No.1 of Dongjiaominxiang Street, Dongcheng District, Beijing, 100730, China.

Brain imaging and behavior

|December 3, 2024

概括

主要开角青光眼 (POAG) 患者表现出大脑活动的改变,视觉区域的功能下降,认知控制网络的活动增加. 这些变化与神经递质系统和视觉功能有关.

科学领域:

神经科学是一个神经科学.
眼科医生眼科眼科
放射学放射学是指放射学

背景情况:

主要开角青光眼 (POAG) 是不可逆转失明的主要原因.
了解POAG的神经生物学基础对于开发有效治疗方法至关重要.
休息状态功能磁共振成像 (rs-fMRI) 提供了对大脑功能改变的见解.

研究的目的:

研究POAG患者的低频波动 (ALFF) 的表面幅度和低频波动 (fALFF) 的分数幅度的变化.
探索这些大脑活动测量和视觉功能之间的关系.
检查大脑变化与分子分析,特别是神经递质系统之间的联系.

主要方法:

在70名POAG患者和45名健康对照人群 (HCs) 上进行了rs-fMRI扫描.
两个样本的t测试比较了POAG和HC之间的大脑活动 (ALFF/fALFF).
斯皮尔曼的相关性分析检查了ALFF/fALFF和眼科参数之间的关系.

主要成果:

POAG患者在视觉网络中表现出ALFF/fALFF降低,并在前对对对和默认模式网络中增加活动.
在体运动网络中观察到减少的fALFF,而在注意力网络中观察到增加的ALFF.
视觉和注意力相关的大脑区域的改变ALFF/fALFF与眼睛参数相关,并与多巴胺系统相关.

结论:

基于表面的ALFF/fALFF分析揭示了POAG中大脑活动变化的明显模式.
这些视觉处理和认知控制网络的变化与视觉功能缺陷有关.
研究结果表明,POAG,神经递质系统以及对心理健康和治疗策略的潜在影响之间存在联系.

关键词:

低频波动的幅度 (ALFF) 是指低频波动的幅度.低频波动的分数振幅 (fALFF) 是低频波动的分数振幅功能性磁共振成像 (fMRI) 是一种功能性磁共振成像技术.主要开角青光眼 (POAG)

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