在糖尿病中丸功能障碍的发病:探索机制和治疗干预措施
Olabimpe Caroline Badejogbin1, Ojichukwuka Ebere Chijioke-Agu2, Makinde Vincent Olubiyi3
1Department of Physiology, School of Basic Medical Sciences, Babcock University, Ilishan-Remo, Ogun State, Nigeria.
Journal of assisted reproduction and genetics
|December 3, 2024
概括
糖尿病通过破坏丸细胞和破坏激素水平,导致男性不孕. 有效的管理需要药物治疗,生活方式改变和向治疗的综合方法,以获得更好的结果.
科学领域:
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
背景情况:
- 糖尿病是一种全球性健康危机,与男性不孕症的增加有关.
- 糖尿病并发症显著影响丸功能,影响生育能力.
- 了解这些影响对于开发有效的干预措施至关重要.
研究的目的:
- 审查糖尿病诱导的丸功能障碍背后的机制.
- 为了确定干预的潜在治疗目标.
- 探索创新和替代治疗策略.
主要方法:
- 在主要的科学数据库 (PubMed,Science Direct,Google Scholar,Web of Science) 进行全面的文献搜索.
- 关键词包括"糖尿病"和"丸功能障碍"以及相关术语.
- 分析详细介绍致病机制和治疗方法的研究.
主要成果:
- 糖尿病损害了的合成,精子生成,并增加了生殖细胞的亡.
- 关键机制包括高血糖,氧化应激,炎症和荷尔蒙失衡.
- 对莱迪格和塞尔托利细胞的损伤是一个显著的后果.
结论:
- 针对特定的生物分子通路提供了一个有前途的治疗策略.
- 基于植物的疗法显示出作为糖尿病丸功能障碍的替代治疗方法的潜力.
- 结合诊断,药物治疗和生活方式改变的多模式方法对于糖尿病患者的男性不孕症管理至关重要.
相关概念视频
Disorders of the Male Reproductive System
325
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
325
Diabetes Mellitus: Overview and Type I Subtype
2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K
Diabetes: Management and Pharmacotherapy
235
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
235
Pathophysiology of Diabetes
866
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
866
Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Infertility in Males
242
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
242


