通过基于风险的设计,增强了注意力缺陷/多动障碍的神经生物学生物标志物差异化
Igor Duarte1,2,3,4, Mauricio Scopel Hoffmann1,3,5,6,7, Giovanni A Salum1,3,8
1Graduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
European child & adolescent psychiatry
|December 3, 2024
概括
基于风险的设计可以通过突出高风险和低风险个体之间的差异来改善注意力缺陷/多动症 (ADHD) 生物标志物的识别. 这种方法提高了临床实践中生物标志物的实用性和验证.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 对注意力缺陷/多动障碍 (ADHD) 的生物标志物翻译面临挑战,原因是受影响个体和对照人群之间的神经生物学措施重叠.
- 基于风险的设计策略可能会提高ADHD生物标志物的实用性和验证性.
研究的目的:
- 评估风险知情设计是否提高了ADHD和无ADHD个体之间的神经生物学测量区别.
- 评估ADHD风险负载对生物标志物差异对未受到ADHD风险负载影响的个体分层的影响.
主要方法:
- 利用来自巴西精神疾病高风险队列的2511名儿童和青少年 (6-14岁) 的数据.
- 在使用多变量临床和社会人口模型的未受影响个体中计算ADHD风险.
- 在ADHD和对照组之间,以及在对照组内的高风险和低风险子组之间,比较了ADHD多基因分数,皮质下体积和执行功能.
主要成果:
- 与一般不受影响的群体相比,患有ADHD的个体显示出更高的多基因分数,较小的皮质下体积和较差的执行功能.
- 将未受影响的个体分为低风险和高风险子组的分层显示,这些生物标志物的差异明显明显 (科恩的d = 0.20到0.60).
- 经过对症状数量进行调整后,风险知情分析仍然显著,与通常消失的简单ADHD与对照对比不同.
结论:
- 基于风险的设计方法显著增加了候选ADHD生物标志物的效果大小.
- 这种方法为评估ADHD和潜在的其他精神健康障碍中的神经生物学对比提供了一个有希望的模型.
更多相关视频
13:09Using Brain Activation nir-HEG/Q-EEG and Execution Measures CPTs in a ADHD Assessment Protocol
Published on: April 1, 2018
10.2K
05:48The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
Published on: June 12, 2020
5.7K
相关概念视频
01:30Attention-Deficit/Hyperactivity Disorder
40
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
40
01:28Human Genetics
534
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
534