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一个酸铜自组装的纳米粒子,通过在瘤细胞中的代谢重编程来增强质亡

Wei Zhang¹, Ziling Chen¹, Chen Xiong¹

¹State Key Laboratory of Biogeology and Environmental Geology, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China.

|December 3, 2024

概括

这项研究引入了一种含铜的纳米粒子 (MHRC@Cu),该纳米粒子可以重编程依赖糖溶解的癌细胞,以增强代谢细胞死亡途径cuproptosis,从而实现显著的瘤生长抑制.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

代谢细胞死亡途径 - - 质亡 (cuproptosis) 在癌症治疗方面显示出有前途.
目前的cuproptosis疗法仅限于依赖于线粒体呼吸的瘤,不包括依赖于糖解的瘤.
瘤中的华堡效应需要策略来克服对铜诱导细胞死亡的抵抗.

研究的目的:

设计一个装有铜的纳米粒子 (MHRC@Cu) 用于代谢重编程.
为了增强依赖糖解的瘤细胞中的cuproptosis.
为更广泛的癌症治疗应用开发一个多功能纳米治疗平台.

主要方法:

开发一种含铜基纳米粒子 (MHRC@Cu).
通过酸性环境和激光照射,MHRC@Cu触发了细胞内Cu2+的释放.
联探针 (MHRC) 重新编程细胞代谢,并增强铜离子的敏感性.

主要成果:

MHRC@Cu有效地重新编程了依赖于糖溶解的细胞,使其转向线粒体呼吸.
2+释放,代谢重编程和芬顿反应 (产生OH) 的协同效应增强了cuproptosis.
在依赖糖解的瘤细胞中达到高达96%的瘤生长抑制.

结论:

MHRC@Cu提供了一种强有力的策略,可以在更广泛的癌细胞中诱导cuproptosis.
纳米粒子通过代谢重编程克服了依赖于糖溶解的瘤中的抗性.
这种方法有可能开发用于癌症治疗的先进自组装纳米治疗平台.

关键词:

这就是cuproptosis.代谢过程中的代谢.酸结合的探针探针.光热和光动力学光热和光动力学.自己组装的纳米粒子.

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