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Updated: Jun 6, 2025

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
09:24

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells

Published on: August 12, 2015

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CDK12-BRCA1信号轴通过p53-介导的细胞衰老来调解与dinaciclib相关的放射敏感性

Natalia García Flores1,2, Diego M Fernández-Aroca1,2,3, Cristina Garnés-García1,2,4

  • 1Laboratorio de Oncología Molecular, Unidad de Medicina Molecular, Instituto de Biomedicina, Universidad de Castilla-La Mancha, Albacete, Spain.

Molecular oncology
|December 3, 2024
PubMed
概括

迪纳西克利布通过抑制CDK12和影响DNA修复途径来增强某些癌症的辐射敏感性. 这一发现支持基于瘤遗传学的个性化癌症治疗.

关键词:
这就是BRCA1的原因.在CDK12中,CDK12就是CDK12.迪纳西克利布 (dinaciclib) 是一种辐射敏感性 辐射敏感性衰老是一种老化.

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