评估基于人口的个性化规划策略,用于头适应性放射治疗
Justin Visak1,2, Chien-Yi Liao1,2, Xinran Zhong1
1Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Journal of applied clinical medical physics
|December 3, 2024
概括
新的自适应性放射治疗计划系统改善了头癌治疗. 与传统方法相比,人工智能和基于知识的规划提供了优越的风险器官节省.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
背景情况:
- 头癌 (HNC) 治疗规划是复杂的,严重依赖于规划师的专业知识.
- 准确的规划目标对于剂量测量约束和强大的在线自适应性放射治疗 (ART) 至关重要.
研究的目的:
- 评估一个新的基于X射线的ART治疗计划系统 (TPS) 版本2.0模拟器.
- 将包括人工智能 (AI) 和基于知识的规划 (KBP) 在内的规划策略与HNC的传统方法进行比较.
主要方法:
- 通过使用Ethos2.0 TPS模拟器重新规划20名HNC患者的回顾性分析.
- 策略包括基于人口的,KBP指导的 (有/没有人类干预) 和AI指导的规划目标.
- 计划在剂量和可交付性方面进行了比较.
主要成果:
- 所有策略都产生了可接受的计划质量;KBP和AI指导的目标改善了处于危险的器官 (OAR) 的节约.
- 人工智能指导的目标显示了最多的OAR节省,对对侧侧腺的平均剂量明显较低.
- 与基于人口和人工智能策略相比,KBP表现出更快的优化时间和更高的调制.
结论:
- 新的Ethos2.0 TPS使用人工智能或KBP生成的目标,生成符合剂量计规划的计划.
- 人工智能引导的目标在HNC治疗计划中提供了优越的OAR节省.
- 这些AI和KBP方法可以适应其他治疗场所,简化在线ART的实施.
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