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在生殖尿路恶性瘤中Nectin-4的阳性:系统性审查
Emanuele Crupi1,2, Tiago Costa de Padua1, Laura Marandino1
1Department of Medical Oncology, IRCCS San Raffaele Hospital, Milan, Italy.
JCO precision oncology
|December 3, 2024
概括
结核素-4 (N4) 在膀 (UBC) 尿癌中高度表达,特别是在转移阶段. 非脑膜性泌尿道癌通常显示较低的N4阳性,这表明N4是UBC治疗的潜在标.
科学领域:
- 在瘤学瘤学.
- 泌尿生殖系统癌症研究
- 分子诊断学 分子诊断学
背景情况:
- 在各种癌症中发现了异常的nectin-4 (N4) 表达,这使得它成为抗体-药物合物的有希望的标.
- N4在膀 (UBC) 泌尿器癌中尤为重要,但其在其他生殖尿路 (GU) 恶性瘤中流行率的数据很少.
研究的目的:
- 系统地审查和分析不同尿生殖系统 (GU) 恶性瘤中的nectin-4 (N4) 阳性率.
- 为了比较尿癌 (UC) 和非尿癌的GU癌症之间的N4表达水平.
主要方法:
- 使用PubMed,MEDLINE和Embase数据库进行了全面的系统文献审查.
- 搜索于2023年3月进行,并于2024年3月更新,遵循系统审查和元分析 (PRISMA) 准则的首选报告项目.
- 分析包括25项评估N4阳性在各种GU瘤的研究.
主要成果:
- 尿素-4 (N4) 阳性在膀 (UBC) 尿癌中很高,在不同阶段的加权平均值为83.1%至90.8%.
- 膀泌尿瘤 (UBC) 与上道泌尿瘤 (UTUC) (WM,62.9%) 相比,表现出更高的N4阳性 (WM,87.1%).
- 非皮质体GU恶性瘤,包括乳头脏细胞癌 (pRCC),染色恐惧RCC (chRCC) 和前列腺癌 (PCa),与UBC相比,N4阳性率较低.
结论:
- 非泌尿器 (GU) 癌症通常比泌尿器癌 (UC) 呈现较低的nectin-4 (N4) 阳性.
- 膀癌中的N4表达因瘤阶段和组织学亚型 (HS) 的存在而异.
- 需要进一步的前性研究来充分阐明N4在GU恶性瘤中的预测和预后意义.
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