慢性胰腺炎不同阶段巨细胞激活的循环生物标志物:试点研究
Rasmus Hagn-Meincke, Srdan Novovic1, Amer Hadi1
1Departments of Gastroenterology and Gastrointestinal Surgery and.
Pancreas
|December 3, 2024
概括
慢性胰腺炎 (CP) 涉及M2巨细胞的激活. 在确定的CP患者中,可溶性CD163 (sCD163) 和可溶性CD206 (sCD206) 的升高表明M2巨细胞激活已晚,有助于诊断.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 生物标志物发现发现
背景情况:
- M2巨细胞激活与慢性胰腺炎 (CP) 病原发生有关.
- 研究基于血液的巨细胞激活标志物可以帮助诊断和分期CP.
研究的目的:
- 为了研究慢性胰腺炎不同阶段的巨细胞激活的血液基标记物.
- 在CP患者和对照组中评估可溶性CD163 (sCD163),可溶性CD206 (sCD206) 和单细胞化学吸引蛋白-1 (MCP-1) 的血度.
主要方法:
- 从73名CP患者 (疑似和确定的) 和40名对照患者的血样本进行横截面分析.
- 与酶相关的免疫吸收试验 (ELISA) 用于量化sCD163,sCD206和MCP-1.
- 回归模型和接收器运行特征 (ROC) 曲线分析被用于统计比较.
主要成果:
- 与对照组相比,确定的CP患者的血sCD163和sCD206显著升高.
- 与可疑CP相比,sCD206水平在确定的CP中也更高.
- 对sCD163 (1.84 mg/mL) 和sCD206 (0.24 mg/mL) 的最佳截止值区分了与AUC-ROC分别为0.65和0.66的对照组的最终CP. MCP-1水平没有显著差异.
结论:
- 在确定的CP患者中,sCD163和sCD206的升高表明M2巨细胞激活.
- 这些生物标志物可能意味着慢性胰腺炎的晚期.
- 这些发现表明sCD163和sCD206作为CP的诊断或分期标记物的潜在实用性.
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