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相关概念视频

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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相关实验视频

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Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
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Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

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在HCC中miRNAs,病原和点.

Guisheng Song1,2, Xiaofan Yu1, Hongtao Shi1,3

  • 1Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

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概括

微RNAs (miRNAs) 是肝癌 (HCC) 的关键调节剂,影响扩散,免疫力和转移. 针对miRNAs为这种致命疾病提供了有前途的诊断和治疗策略.

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科学领域:

  • 在瘤学瘤学.
  • 分子生物学分子生物学
  • 遗传学 遗传学 是一个

背景情况:

  • 肝细胞癌 (HCC) 是一个主要的全球健康问题,由复杂的分子变化驱动.
  • 微RNAs (miRNAs) 是小的非编码RNAs,它们对HCC的基因表达有着重要的调节作用.
  • miRNAs影响关键的致癌途径,包括增殖,亡,血管新生,上皮细胞-介质细胞过渡 (EMT) 和免疫微环境.

研究的目的:

  • 为提供miRNA在HCC病变发生中的作用的全面审查.
  • 探索miRNAs在肝癌中的诊断和治疗潜力.
  • 讨论基于miRNA的HCC干预的当前挑战和未来方向.

主要方法:

  • 文献综述巩固了关于miRNA生物发生,功能和HCC临床应用的研究.
  • 对miRNA参与HCC特征的分析:扩散,亡,血管新生,转移,免疫调节和耐药性.
  • 对miRNA稳定性的检查,用于非侵入性诊断和治疗性输送策略.

主要成果:

  • miRNA失调是HCC发展和进展的核心.
  • miRNAs调节关键的致癌途径和瘤免疫微环境.
  • 生物流体中的稳定miRNA为非侵入性HCC诊断提供了潜力.
  • 基于miRNA的疗法对向性HCC治疗和克服药物耐药性有希望.

结论:

  • miRNAs是肝癌的关键调节剂,具有重要的诊断和治疗影响.
  • 向miRNA途径为新型HCC治疗提供了有希望的途径,其疗效提高,毒性降低.
  • 对miRNA传递和临床翻译的进一步研究对于实现其在管理HCC方面的全部潜力至关重要.