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相关概念视频

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Functions of Thyroid Hormones01:18

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Antiasthma Drugs: Methylxanthines01:24

Antiasthma Drugs: Methylxanthines

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Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

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Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
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Major Hormones and Their Functions01:27

Major Hormones and Their Functions

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Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
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相关实验视频

Updated: Jun 6, 2025

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
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Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

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珀戈利德甲基酸盐的使用不会降低血中甲状腺激素度和甲状腺功能的马.

Martyna M Jargielo, Janice E Kritchevsky, François-René Bertin

    American journal of veterinary research
    |December 3, 2024
    PubMed
    概括
    此摘要是机器生成的。

    珀戈莱德治疗没有影响马类甲状腺功能或血液甲状腺激素水平. 低甲状腺激素度在患有下垂体帕斯介质功能障碍的马中可能是由于这种情况本身.

    关键词:
    在内分泌学内分泌学.甲状腺功能低下症 甲状腺功能低下症非甲状腺疾病综合征pituitary pars 中间功能障碍 pituitary pars 中间功能障碍甲状腺增生激素释放激素的释放激素.

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    Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
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    In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus
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    科学领域:

    • 马类内分泌学 马类内分泌学
    • 兽医药理学 兽医药理学 兽医药理学

    背景情况:

    • 珀戈利德用于治疗马匹的垂体中介性皮质功能障碍.
    • 它高度与蛋白质结合,引发了人们对潜在的甲状腺激素取代的担忧.

    研究的目的:

    • 为了研究珀戈利德对马类甲状腺功能的影响.
    • 为了确定珀戈利德是否会改变血中的甲状腺激素度.

    主要方法:

    • 一项观察性队列研究,涉及6匹用pergolide治疗的马.
    • 在治疗前,治疗期间和治疗后测量了甲状腺激素水平 (总T4,总T3,自由T4).
    • 进行了激素释放激素 (TRH) 刺激测试.

    主要成果:

    • 佩戈利德的使用并没有显著改变T4总水平.
    • TRH刺激导致甲状腺激素的预期增加.
    • 没有发现pergolide对任何甲状腺激素度的显著影响.

    结论:

    • 珀戈利德似乎不会影响马的甲状腺激素度.
    • 观测到的甲状腺激素水平较低的马体下垂体中介性乱可能与疾病有关,而不是药物.