百日咳的临床概况转变,严重程度,在三级医院的预测:在中国南部的COVID-19之前,期间和之后的一项比较研究
Shufeng Tian1, Yulan Chen1, Qiru Su1
1Department of Infectious Diseases, Shenzhen Children's Hospital, Shenzhen, China.
Journal of infection and public health
|December 3, 2024
概括
流行性咳流行病学转移到大龄儿童的流行病后,严重程度上升和宏类耐药性. 疫苗接种仍然具有保护性,但需要新的策略来应对不断变化的百日咳模式.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 百日咳 (百日咳) 在全球范围内仍然是一个重大的公共卫生问题.
- 由于COVID-19的流行,影响了儿童常规免疫接种和疾病监测.
- 了解大流行期间和之后的百日咳趋势对于有效控制至关重要.
研究的目的:
- 分析深儿童医院的百日咳流行病学,临床特征和抗菌素耐药性.
- 评估COVID-19大流行对百日咳疾病模式的影响.
- 开发一种严重百日咳的预测模型.
主要方法:
- 使用PCR和培养数据对百日咳病例 (2019-2024) 的回顾性分析.
- 对人口统计,临床,疫苗接种和实验室数据的评估.
- 对抗菌素敏感性测试和严重病例指标分析.
主要成果:
- 百日咳病例在2023年底增加,从婴儿到学龄儿童 (4-11岁) 的明显转变.
- 宏类耐药性从2019年的46.5%大幅增加到2024年的97.3%.
- 流行后,临床严重性,并发病和需要抗生素的变化增加;疫苗接种保护严重疾病.
结论:
- 百日咳流行病学在流行病后转向了老年儿童,其特点是严重程度增加和高抗宏类药物耐药性.
- 迫切需要优化疫苗接种计划,并制定新的管理策略.
- 严重 pertussis 的预测指标包括白血细胞计数,LNR,血小板计数,病和肺炎.
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