孕妇在怀孕前和怀孕期间接触细颗粒物,以及出生缺陷的风险:基于人口的研究
Shihan Zhen1, Na Li2, Yan Li3
1School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen 518055, China.
Ecotoxicology and environmental safety
|December 3, 2024
概括
在怀孕前和怀孕期间,母亲接触细颗粒物 (PM2.5) 会显著增加出生缺陷的风险. 减少空气污染暴露对于改善出生结果至关重要.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 公共卫生 公共卫生
背景情况:
- 流行病学研究将孕产妇受到的空气污染暴露与不良出生结果联系起来.
- 关于受污染的发展中国家的细颗粒物 (PM2.5) 和总出生缺陷的数据有限.
研究的目的:
- 评估怀孕前和怀孕期间母亲PM2.5暴露与出生缺陷风险之间的关联.
- 调查PM2.5对中国宁省出生缺陷发生的影响.
主要方法:
- 一项大规模的研究包括 16,080 个有缺陷的出生和 567,483 个对照 (2014-2019).
- 基于卫星的PM2.5数据 (1公里分辨率) 评估了暴露.
- 后勤回归模型估计了PM2.5暴露与出生缺陷风险之间的关联.
主要成果:
- 增加10μg/m3的PM2.5与出生缺陷的几率比率更高 (1.68预孕,怀孕期间2.41).
- 在PM2.5暴露和总出生缺陷之间观察到J形的关联.
- 在这两个时期中增加的PM2.5暴露显示出最高的风险 (OR:4.43).
结论:
- 在怀孕前和怀孕期间,母亲的PM2.5暴露与出生缺陷风险的增加有关.
- 在怀孕前和怀孕期间减少空气污染的暴露,可能会给新生儿带来显著的健康益处.
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