重塑战场:在中国的金黄色葡萄球菌中进行了十年的克隆战争
Wangxiao Zhou1, Ye Jin2, Pan Chen3
1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Clinical Laboratory Center, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
概括
中国的金黄色葡萄球菌的基因组流行病学显示,甲素耐药菌株发生了转变,ST59取代ST239占主导地位. 梅西林敏感菌株保持稳定,但两者都可以演变为MRSA. 这影响了抗微生物药物管理.
科学领域:
- 基因组流行病学 基因组流行病学
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 在中国对黄金葡萄球菌 (MRSA和MSSA) 进行了有限的综合基因组研究.
- 需要评估中国S. aureus的基因组流行病学和种群动态.
研究的目的:
- 评估中国S. aureus的基因组流行病学特征.
- 为了了解十多年来S. aureus的种群动态.
主要方法:
- 全基因组测序和耐药性表型测定3848个S. aureus血流感染 (2011-2020) 的分离物.
- 对抗性/病毒性基因和移动遗传元素的分析.
- 流行血统的时间尺度上的遗传学分析.
主要成果:
- 确定了315种序列类型 (ST),其中有205种新型.
- MRSA 种群结构发生了转变,ST59 取代ST239 占主导地位.
- 在MSSA系 (ST188,ST7,ST22,ST5,ST398) 保持稳定.
- 通过SCCmec的收购,MSSA可以演变成MRSA.
- PVL+MRSA分离物增加;整体MRSA显示耐药性基因降低和抗微生物敏感性增加.
结论:
- 在中国,S. aureus的基因组景观的转变需要量身定制的抗菌药物管理.
- 加强对过去十年S. aureus流行病学趋势的了解至关重要.
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