长非编码RNA及其在乳腺癌病原和耐药性中的作用:导航非编码格局的综述
Tohada M Al-Noshokaty1, Gharieb S El-Sayyad2, Rehab Abdelhamid1
1Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt.
Experimental cell research
|December 3, 2024
概括
长非编码RNAs (lncRNAs) 在乳腺癌 (BC) 的发展和耐药性方面发挥着关键作用. 了解在PI3K,MAPK和NF-kB等关键途径中的lncRNA功能对于推进向治疗至关重要.
科学领域:
- 分子生物学分子生物学
- 基因组学就是基因组学.
- 癌症研究 癌症研究
背景情况:
- 尽管有针对性的治疗进展,但乳腺癌 (BC) 仍然是一个主要的健康问题.
- 高通量测序使转录学成为可能,揭示了非编码RNA (ncRNA) 在疾病中的作用.
- 长非编码RNAs (lncRNAs) 与癌症发展有关,但许多功能尚未定义.
研究的目的:
- 总结目前关于lncRNA在乳腺癌中的作用的知识.
- 专注于lncRNA参与PI3K,MAPK,NF-kB通路,以及缺氧.
- 探索乳腺癌中 lncRNA介导的抵抗机制.
主要方法:
- 对有关lncRNAs和乳腺癌的现有科学文献的综述.
- 对专注于特定分子通路 (PI3K,MAPK,NF-kB) 的研究进行分析.
- 检查对缺氧和 lncRNA介导的耐药性的研究.
主要成果:
- lncRNAs越来越多地被认为是乳腺癌瘤发生的关键调节者.
- 特定的 lncRNAs 影响关键信号通路,影响癌症的进展.
- lncRNAs有助于治疗耐药性,突出其临床相关性.
结论:
- 需要进一步的研究来阐明BC中许多lncRNAs的精确分子机制.
- 针对 lncRNAs 提供了针对乳腺癌的新疗法策略的潜力.
- 了解ncRNA路径相互作用对于克服治疗耐药性至关重要.
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
02:56Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
01:22MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
01:20Types of RNA
5.6K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
5.6K
03:03mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K
02:40Cancer Stem Cells and Tumor Maintenance
4.8K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.8K