术后复发的最佳治疗方法:救援辐射是否适用于局部复发?
Yuri Taniguchi1, Takao Shigenobu2, Akiko Hayashi3
1Department of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, Yokohama, Japan; yuriteito@gmail.com.
Anticancer research
|December 3, 2024
概括
手术后非小细胞肺癌 (NSCLC) 复发的患者在局部区域复发时的生存率更好. 拯救局部治疗,包括放射治疗 (RT) 和并发化学放射治疗 (cCRT),显示出治疗局部区域复发的希望.
科学领域:
- 在瘤学瘤学.
- 胸部外科手术 胸部外科手术
- 辐射瘤学 辐射瘤学
背景情况:
- 成功切除非小细胞肺癌 (NSCLC) 患者的结局尚未完全理解.
- 术后局部区域性复发的最佳治疗方法尚未确定.
研究的目的:
- 分析NSCLC患者切除后的生存结果.
- 评估救援局部疗法的有效性,以应对局部区域性复发.
主要方法:
- 对694名接受R0切除的NSCLC患者 (2013-2022) 的回顾性审查.
- 基于局部区域与远程复发的生存分析.
- 对放射治疗 (RT) 和并发化疗放射治疗 (cCRT) 对于局部区域性复发的评估.
主要成果:
- 在694名患者中,有150名患者出现了复发 (54个局部区域,96个远程).
- 局部区域复发 (55.9个月) 和远程复发 (22.3个月) 的平均整体存活时间 (OS) 显著好于局部区域复发 (55.9个月).
- 针对局部复发的救援局部治疗 (cCRT/RT) 的中位数PFS为13.3个月,OS为60.4个月,耐受性良好.
结论:
- 切除后NSCLC的局部区域复发的预后比远程复发更好.
- 包括cCRT和RT在内的救援局部治疗是局部区域复发的潜在有效和耐受治疗方法.
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