在清细胞细胞癌患者中缺血性中风风险的预测性诺莫грам
Jie Wen1,2, Yi Rong1,2, Yinbo Kang1,2
1Department of Urology, First Hospital of Shanxi Medical University, No.85 Jiefang South Road, Yingze District, Taiyuan, Shanxi Province, China.
Scientific reports
|December 3, 2024
概括
清细胞细胞癌 (ccRCC) 患者面临高血性中风风险. 一种新的诺莫格拉姆模型使用WHO/ISUP等级和D-度等因素准确预测这种风险,有助于早期干预.
科学领域:
- 瘤学和神经病学 在
- 心血管研究研究心血管研究
背景情况:
- 清细胞细胞癌 (ccRCC) 和缺血性中风是全球重要的健康问题.
- 已知ccRCC与缺血性中风风险增加之间存在关联.
研究的目的:
- 在ccRCC患者中调查与缺血性中风风险相关的瘤相关因素.
- 开发和验证ccRCC患者缺血性中风的预测性诺莫格拉姆模型.
主要方法:
- 对接受切除术的ccRCC患者的回顾性分析 (2013年1月 - 2022年5月).
- 数据分为培训 (70%) 和验证 (30%) 队列.
- 使用后勤回归和LASSO回归识别的预测因素.
主要成果:
- 开发了一种纳米图,包含了六个预测因素:WHO/ISUP等级,糖尿病,高血压,LDL-C,年龄和D-二次数.
- 诺米图表显示出良好的预测性能 (AUC 0.816培训,0.775验证).
- 该模型显示出出色的校准和临床适用性.
结论:
- 世卫组织/ISUP等级是ccRCC中缺血性中风风险的重要相关因子.
- 开发的诺米图有效地识别出高风险发生缺血性中风的ccRCC患者.
- 这种工具有助于早期治疗策略,并有可能改善患者的治疗结果.
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