平行肠道到大脑的通路协调了养行为
Hongyun Wang1,2, Runxiang Lou1, Yunfeng Wang1
1Chinese Institute for Brain Research, Beijing, China.
Nature neuroscience
|December 3, 2024
概括
孤独通道的尾部核 (cNTS) 集成了用于养的信号. 不同的cnts神经元类型通过不同的途径调节摄入速度和和.
科学领域:
- 神经科学是一个神经科学.
- 身体生理学 身体生理学
- 胃肠病学 胃肠病学
背景情况:
- 孤独通道 (cNTS) 的尾部核整合了整体受体信号,但它如何驱动养行为尚不清楚.
- 了解cNTS神经元功能对于破译养调节至关重要.
研究的目的:
- 研究cNTS细胞类型在调节养行为中的独特作用.
- 阐明cNTS介导的养控制背后的感觉路径和时间动态.
主要方法:
- 对18条cNTS-Cre鼠标线路的分析.
- 在养过程中对9种cnts细胞类型的动态进行分类.
- 调查阴道 afferent 和门静脉-脊柱上升通道.
主要成果:
- Th+cNTS神经元使用阴道输入来编码食道膨胀和吞大小,调节摄入速度.
- Gcg+ cNTS神经元通过门静脉-脊柱通路感知肠道的营养和热量,影响和偏好.
- 不同的cnts亚型表现出独特的时间动态和感官模式.
结论:
- cNTS亚型在功能上是针对养监管的不同方面进行专业化的.
- 特定的感官路径和时间动态区分cNTS神经元在控制摄入和和方面的作用.
- 研究结果显示,在cNTS中,有一个复杂的,多路径的系统,用于协调养监管.
相关概念视频
Neural Regulation
39.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.1K
Enteric Nervous System: Regulation of GI Motor Activity
299
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
299
Indirect Motor Pathways
1.4K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
1.4K
Physiology of the Gastrointestinal System I: Ingestion and Propulsion
265
The physiology of the gastrointestinal system begins with ingestion as food enters the mouth.
265
Major Somatic Sensory Pathways
892
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
892
Cephalic Phase of Digestion
952
The process of digestion is composed of three stages – cephalic, gastric, and intestinal – each with a distinct control center. The cephalic phase is the first stage, and it starts even before the food enters the stomach. It is controlled by the central nervous system and is initiated by any food-related sensory stimuli, such as the sight and smell of food, which send signals to the brain. While eating, the taste receptors intensify these signals, which travel to the cerebral cortex...
952


