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Updated: Jun 5, 2025

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
13:55

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Published on: February 3, 2013

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动态O-GlcNAcylation控制了B细胞早期发育过程中的V(D) J重组中的长距离染色质相互作用

Bong Chan Jeon1,2, Yu-Ji Kim1, Ae Kyung Park3

  • 1Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.

Cellular & molecular immunology
|December 3, 2024
PubMed
概括

一种蛋白质修饰的O-GlcNAcylation对于B细胞中的免疫球蛋白基因重组至关重要. 抑制O-GlcNAcylation破坏了V(D) J重组,影响了抗体的多样性.

关键词:
凝聚力复杂的凝聚力复杂.在DDX5 DDX5 中.这是一种O-GlcNAcylation.V(D) J的重组组合.通过YY1和CTCF的DNA结合.

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