综合素调节突触囊泡释放:中枢神经系统中的机制和专业的视网膜带突触
Yun-Zhi Li1, Yu Wang2, Qing Jiao1
1Department of Ophthalmology, The Second Norman Bethune Hospital of JiLin University, Changchun, 130041, China.
Cell communication and signaling : CCS
|December 3, 2024
概括
复合素 (CPX) 是关键蛋白调节神经递质在大脑和视网膜中的释放. 本综述侧重于视网膜带突触中的CPX3/4并建议针对视觉和神经障碍的CPX向疗法.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 眼科医生 眼科 眼科
背景情况:
- 突触带对于视觉通路中的感觉信号传输至关重要.
- 复合素 (CPX) 调节SNARE复合组合,控制突触囊泡融合和神经递质释放.
- 特定的CPX异型 (CPX1/2) 在中枢神经系统 (CNS) 中起作用,而其他异型 (CPX3/4) 则对视网膜带突触至关重要.
研究的目的:
- 审查CPX在中枢神经系统和视网膜带突触中释放突触囊的调节.
- 阐明在视网膜中CPX3/4功能的特定机制.
- 探索CPX在视网膜疾病中的作用,并提出治疗策略.
主要方法:
- 对现有关于复合素在突触传播中的功能研究的文献综述.
- 对中枢神经系统中CPX异型特异性的分析与视网膜带突触的分析.
- 假设CPX参与视网膜疾病病理学的机制.
主要成果:
- 在动态光条件下,CPX3/4异型对视网膜突触可塑性,昼夜节律适应和视觉功能至关重要.
- CPX和带状突触的功能障碍与各种非视网膜疾病有关.
- 了解CPX3/4视网膜功能为探索其在视网膜疾病中的作用提供了基础.
结论:
- 通过视网膜带突触,CPX3/4在调节视觉功能方面发挥着至关重要的作用.
- CPX 功能障碍可能导致视网膜和中枢神经系统疾病.
- 准CPX为与突触功能障碍相关的疾病提供了潜在的治疗途径.
相关概念视频
Fusion of Secretory Vesicles with the Plasma Membrane
11.0K
Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
11.0K
Overview of Secretory Vesicles
8.4K
Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
8.4K
Pinching-off of Coated Vesicles
3.1K
Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
3.1K
Chemical Synapses
8.7K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
8.7K
Clathrin Coated Vesicles
6.8K
Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
6.8K
Ligand-Gated Ion Channel Receptor: Gating Mechanism
2.1K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
2.1K


