社会脆弱性与晚期乳腺癌呈现和全因死亡率有关:一项回顾性队列研究
Kayla A Councell1, Ann M Polcari2, Rachel Nordgren3
1Department of Surgery, University of Chicago, 5841 S. Maryland Ave., MC5030, Chicago, IL, 60637, USA. Kayla.polcari@uchicagomedicine.org.
Breast cancer research : BCR
|December 4, 2024
概括
社会脆弱性与晚期乳腺癌诊断和较低的生存率有关. 使用社会脆弱性指数 (SVI) 识别弱势群体可以帮助减少乳腺癌护理方面的差异.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 健康的社会决定因素
背景情况:
- 尽管治疗和查方面取得了进展,但乳腺癌死亡率存在持续的差异.
- 评估健康的社会决定因素对乳腺癌结果的影响是复杂的,因为不同的测量方法.
- 本研究研究了社会脆弱性与诊断时乳腺癌阶段与死亡率之间的关联,使用标准化测量方法.
研究的目的:
- 检查社会脆弱性和诊断时乳腺癌阶段之间的关系.
- 评估乳腺癌患者的社会脆弱性和全因死亡率之间的关联.
- 确定社会脆弱性指数 (SVI) 在解决乳腺癌护理差异方面的有用性.
主要方法:
- 利用了女性乳腺癌患者 (2012-2019) 的机构癌症注册数据.
- 分配的社会脆弱性指数 (SVI) 基于患者人口普查通道数据的排名.
- 采用多项逻辑回归和Cox比例危险模型进行分析,并对相关共变量进行调整.
主要成果:
- 在诊断时,增加SVI与晚期 (III/IV) 乳腺癌的更高几率有关.
- 在SVI的每一个十分之一的增加与11-15%更大的晚期诊断的几率相关.
- 较高的SVI与6%的全因死亡风险增加以及最脆弱四分位数的人的1.5倍风险增加有关.
结论:
- 在社会上脆弱的人群中,乳腺癌的发病率更高,存活率更差.
- 该SVI可以识别患有延迟诊断和增加死亡率的高风险的患者.
- 乳腺癌统计是一个有价值的工具,用于有针对性的资源分配和干预措施,以减少乳腺癌差异.
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