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饮食质量评分和中国女孩中部早发性风险:一项案例对照研究
Yujie Qin1, Hongyang Deng2, Mengnan Lu1
1Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Clinical endocrinology
|December 4, 2024
概括
通过更高的儿童饮食炎症指数 (C-DII) 评分来表明的促炎症饮食与增加的中央早熟青春期 (CPP) 风险有关. 相反,抗炎饮食,如通过调整的饮食方法来阻止高血压 (aDASH) 评分来衡量的饮食,可能有助于预防女孩的CPP.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 饮食显著影响内分泌系统的发育,包括青春期的开始.
- 中部早发性青春期 (CPP) 是一种青春期比正常时间更早开始的情况.
- 了解饮食因素对于预防CPP至关重要.
研究的目的:
- 研究中国女孩中饮食质量和具有CPP的促炎饮食之间的关联.
- 评估特定饮食指数在CPP风险中的作用.
- 探索血清炎症标志物和CPP之间的关系.
主要方法:
- 一项病例控制研究,涉及112名CPP女孩和131名健康对照.
- 通过食物频率问卷评估的饮食摄入量.
- 计算儿童饮食炎症指数 (C-DII),中国儿童饮食指数 (CCDI),停止高血压的饮食方法 (DASH) 评分和调整后的DASH (aDASH) 评分.
- 后勤回归分析以确定饮食和CPP风险之间的关联.
主要成果:
- 较高的C-DII得分与CPP风险增加有显著的相关性 (P为趋势=0.034).
- 较高的aDASH分数与CPP风险降低显著相关 (趋势P=0.048).
- 在CPP病例中观察到血清中白蛋白-6 (IL-6) 水平升高,与CPP风险呈正相关性 (趋势P=0.006).
结论:
- 以高质量和抗炎性质为特征的饮食模式可能在预防CPP方面发挥作用.
- 减少促进炎症的饮食摄入量可能是预防女孩CPP的一种策略.
- 对CPP的饮食干预措施的进一步研究是有必要的.
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