通过指导方针成功修改现有的乙型肝炎查计划,建议在初级保健机构进行乙型肝炎查
Toni Herta1,2,3, Anna Joachim-Richter4, David Petroff5
1Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.
Alimentary pharmacology & therapeutics
|December 4, 2024
概括
在德国,D型肝炎病毒 (HDV) 查仍然很低,前性方法显示了在乙型肝炎表面抗原 (HBsAg) 阳性个体中改善检测的潜力. 建立后勤先决条件是基于人口的HVV测试的关键.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 欧洲指导方针提倡在所有乙型肝炎表面抗原 (HBsAg) 阳性个体中进行乙型肝炎病毒 (HDV) 查.
- 德国目前的HDV查率不足,突显了临床实践中的差距.
研究的目的:
- 在初级保健机构内分析抗HDV查率.
- 通过"检查35+"计划,在35岁及以上的HBsAg阳性个体中实施和评估潜在的HDV查策略.
主要方法:
- 在德国11个实验室中,从2012年至2021年对HBsAg阳性患者的抗HDV和HDVRNA测试率的回顾性分析.
- 来自"检查35+"计划 (2022-2023) 的HBsAg阳性样本对抗HDV的前性查,随后对阳性病例进行HDVRNA检测.
主要成果:
- 追溯来看,只有20%的HBsAg阳性病例被测试为抗HDV,阳性率为5.1%. 其中,40%的人进行了高强度病毒RNA测试,46%的人呈阳性.
- 未来,在"检查35+"计划中,60%的HBsAg阳性个体进行了抗HDV测试,结果为2.6%的阳性率. 在这些病例中,只有22%的HDV RNA测试是可能的,其中有一个阳性结果.
- 在前阶段,样本数量不足和后勤错误限制了40%的HBsAg阳性病例的抗HDV测试.
结论:
- 追溯数据证实,在常规临床护理中,抗HDV查不足.
- 未来的查表明,将高强度病毒检测纳入现有的乙型肝炎查计划是一个可行的模型.
- 成功的基于人口的HDV查需要强大的后勤支持和确定的先决条件.
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