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叉头盒 N1 可能是一个新的生物标志物和预后指标,用于患有状细胞肺癌的患者

Xi Wang^1,2, Caihua Zhang³, Bao-Jun Duan²

¹Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.

International journal of medical sciences

|December 4, 2024

概括

叉头盒 N1 (FOXN1) 在肺状细胞癌 (LUSC) 中显著升高. 在LUSC患者中,高FOXN1表达与较差的存活率相关,这表明FOXN1是潜在的预后生物标志物.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

叉头盒 N1 (FOXN1) 在肺状细胞癌 (LUSC) 中的作用尚不清楚.
这项研究研究了LUSC中的FOXN1表达及其临床意义.

研究的目的:

评估LUSC组织中的FOXN1表达水平与正常肺组织相比.
在LUSC患者中探索FOXN1表达和临床参数之间的相关性.
评估FOXN1作为LUSC.的潜在预后生物标志物.

主要方法:

使用公共数据库和免疫组织化学 (IHC) 分析FOXN1基因表达.
在LUSC和正常肺组织中对FOXN1表达的比较.
统计分析包括 χ2 测试,费舍尔的精确测试,卡普兰-梅尔,威尔科克森测试和考克斯的比例危险模型.

主要成果:

在LUSC组织中,FOXN1表达显著高于正常肺组织 (P < 0.01).
在98.8%的LUSC病例中观察到高FOXN1表达,与LUSC等级,淋巴结转移,远程转移和疾病阶段相关 (P <0.05).
增加FOXN1表达与LUSC患者的生存结果较差有关 (P <0.05).

结论:

在LUSC中,FOXN1经常过度表达.
增加FOXN1表达作为LUSC患者的负预后指标.
福克斯N1有可能成为一种新的生物标志物和LUSC.的预后工具.

关键词:

生物标志物生物标志物临床特征临床特征这就是FOXN1的原因.免疫组织化学免疫组织化学肺状细胞癌是肺的平细胞癌.预测预后预测预测

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