凝血与胃癌预后之间的关系:系统性审查和元分析
Lihui Zhu1,2,3, Shuo Liu4,2,3, Da Wang5,2,3
1School of Clinical Medicine, Ningxia Medical University, Yinchuan, China.
Current therapeutic research, clinical and experimental
|December 4, 2024
概括
升高的d-二元 (D-D),纤维素原 (FIB) 和血小板 (PLT) 水平预测胃癌的预后不佳. 这些凝血指标与晚期和淋巴结转移有关,突出显示了它们的预后价值.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 医学统计 医学统计
背景情况:
- 癌症患者经常表现出高凝血状态,导致死亡率增加.
- 凝血指标是胃癌的潜在预后因素,需要进一步调查.
研究的目的:
- 进行一项元分析,探索凝血标志物与胃癌预后之间的关联.
- 评估特定凝血指标对胃癌总生存率和临床病理学特征的预测价值.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Cochrane Library) 进行了系统的文献搜索,截至2024年2月.
- 数据提取和选由两名独立审查员进行.
- 分析利用随机效应或固定的效应模型来计算总生存和临床病理事件的概率的危险比率 (HR) 和几率比率 (OR).
主要成果:
- 分析包括来自64项研究的数据.
- 增加的d-二元 (D-D),纤维素原 (FIB) 和血小板 (PLT) 水平与胃癌死亡率的增加显著相关 (HRs从1.16到1.85不等).
- 这些指标还与晚期临床病理阶段 (ORs 1.84-2.25) T阶段 (ORs 2.22-2.38) 和淋巴结转移 (ORs 1.51-1.79) 相相关.
结论:
- D-二聚合物,纤维素和血小板计数是胃癌预后的重要预测因素.
- 这些凝血标记与晚期疾病阶段和淋巴结转移的更高可能性有关.
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