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Updated: Jun 5, 2025

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets
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Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets

Published on: March 12, 2019

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蛋白质-联结体晶体结构中基抑制剂和联结体的特定辐射损伤

Matthew J Rodrigues1,2, Marc Cabry1,2, Gavin Collie1,2

  • 1Centre for Cancer Drug Discovery The Institute of Cancer Research 15 Cotswold Road Sutton LondonSM2 5NG United Kingdom.

Journal of applied crystallography
|December 4, 2024
PubMed
概括

在X射线衍射过程中的特定辐射损伤可以在药物分子中切割碳-素键. 这项研究揭示了这种损害对蛋白质连接体结构和数据质量的影响,并提供了缓解策略.

关键词:
基联结物是基联结物.蛋白联体复合体中的蛋白联体.辐射损伤 辐射损伤基于结构的药物设计.

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