循环节偏好与加速计衍生的睡眠-觉醒周期之间的错位与心脏代谢疾病的风险增加
Yue Chen1, Tingting Geng2, Xinming Xu1
1Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Clinical Research Unit, Institute of Clinical Medicine, Zhongshan Hospital, Fudan University, Xuhui District, Shanghai, China.
JACC. Advances
|December 4, 2024
概括
循环失调,睡眠-清醒周期的不平衡,增加了心脏代谢疾病的风险,如2型糖尿病和冠心病. 与身体时钟保持一致的睡眠对心血管健康至关重要.
科学领域:
- 时间生物学 时间生物学
- 心血管流行病学心血管流行病学
- 睡眠医学 睡眠医学
背景情况:
- 昼夜失调,睡眠-清醒周期的破坏和心脏代谢疾病 (CMD) 之间的联系需要进一步澄清.
- 了解这种关系对于针对预防慢性疾病的公共卫生倡议至关重要.
研究的目的:
- 为了前性地研究昼夜失调与心血管疾病发生率之间的关联,特别是2型糖尿病 (T2D),冠心病 (CHD) 和中风.
- 探索潜在的潜在机制,将昼夜失调与CMD联系起来.
主要方法:
- 利用了来自60,965名没有先前存在的CMD的英国生物库参与者的数据,平均跟踪7.9年.
- 通过比较自我报告的时间型与加速计衍生的睡眠时间来评估循环错位.
- 考克斯的比例危险模型被用来分析昼夜失调和事件CMD之间的关联.
主要成果:
- 观察到昼夜不整齐与T2D和CHD风险增加之间存在U形关联.
- 晚期和晚期的昼夜失调都会增加T2D风险,而晚期失调也会增加心脏病风险.
- 在T2D的女性和CHD的年轻人中,相关性更为明显;早期的年代型与较高的T2D风险有关.
结论:
- 晚期和晚期的昼夜失调都与心脏代谢疾病风险增加有关.
- 保持睡眠-清醒周期和个人昼夜偏好之间的协调可能会带来显著的健康益处.
- 这些发现强调了昼夜健康在预防慢性疾病方面的重要性.
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