患有Fontan循环和死亡率相关的患者功能恶化
Gaston van Hassel1, Dion Groothof2, Johannes M Douwes1
1Center for Congenital Heart Diseases, Paediatric Cardiology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
JACC. Advances
|December 4, 2024
概括
患有Fontan循环的患者经历的功能下降速度比健康人更快. 这种恶化与较高的NT-proBNP水平和增加的死亡风险有关.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 儿童心脏病学 儿童心脏病学
背景情况:
- 功能障碍是已知的心血管疾病风险因素.
- 对于Fontan循环患者的功能变化知之甚少.
- 这项研究探讨了这一群体中功能恶化的患病率和因素.
研究的目的:
- 为了研究Fontan循环患者的功能过程.
- 为了确定与功能恶化相关的因素.
- 检查功能和死亡率之间的关联.
主要方法:
- 在11年内对82名Fontan循环患者进行了长度研究.
- 基于肌素的估计膜过率 (eGFRcr) 的测量.
- 评估了cystatin C,NT-proBNP,并使用线性混合效应模型和联合模型进行生存分析.
主要成果:
- 基线时的中位数年龄为20岁.
- 12%的人通过eGFRcr患有功能障碍,24%的人通过eGFRcys.
- eGFRcr下降了1.36毫升/分钟/1.73米2/年,比健康对照更快.
- 较高的基线NT-proBNPz-score与更快的eGFRcr下降相关.
- 较大的eGFRcr下降与全因死亡率有关.
结论:
- 与健康个体相比,Fontan循环患者表现出加速的eGFRcr下降.
- 基线NT-proBNPz-score的升高预测了更快的功能恶化.
- 渐进的eGFRcr下降是该队列中死亡率的重要预测因素.
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