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双向异种聚合物PET追踪剂 [¹⁸F]在风湿性关节炎患者中AlF-FAPI-RGD:一个试点探索性研究

Hao Wang¹, Wei Su², Limeng He¹

¹Department of Nuclear Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

|December 4, 2024

概括

使用[18F]AlF-FAPI-RGD的新型PET/CT成像有效评估类风湿性关节炎 (RA) 活动和治疗反应. 这种双重准的追踪器对亚临床RA和相关的肺部疾病的早期检测充满希望.

科学领域:

核医学就是核医学.
放射化学放射化学是指辐射化学.
类风湿病学类风湿病学

背景情况:

纤维细胞样同胞细胞和血管生成是类风湿性关节炎 (RA) 发病的关键驱动因素.
准确评估RA疾病活性和治疗反应对于患者管理至关重要.

研究的目的:

评估[18F]AlF-FAPI-RGD PET/CT成像用于评估活跃RA患者的疾病活性和治疗反应的疗效.
探索标记器在检测亚临床RA和相关肺部疾病方面的潜力.

主要方法:

一项前性研究,涉及28名活跃RA的参与者.
[18F]AlF-FAPI-RGD PET/CT成像在基线和治疗3个月后进行.
对成像参数 (PJC,PAI,SUVmax) 与临床评估和传统成像进行比较.

主要成果:

[18F]AlF-FAPI-RGD PET/CT产生了高质量的图像,在受影响的关节中显著吸收.
与临床计数相比,追踪器显示受影响关节的检测率更高.
在治疗响应者中,成像参数显著下降,与临床改善相关.
在RA患者中成功识别了非典型呼吸道症状的肺病变.

结论:

[18F]AlF-FAPI-RGD PET/CT是客观评估RA疾病活性和治疗反应的有希望的工具.
这种成像模式可能有助于早期检测亚临床RA和间歇性肺病.

关键词:

[18F]AlF-FAPI-RGD PET/CTCT 是一个可靠的方法.纤维细胞激活蛋白的激活蛋白.整体的整体是整体的新血管生成新血管生成类风湿性关节炎类风湿性关节炎

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