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Updated: Jun 5, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
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Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

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通过调节MMP1-PD-L1轴,SPHK1促进了HNSCC的免疫逃避

Qi Fang1,2,3,4, Xiao Chen5,6, Fei Cao1,2,3,4

  • 1Department of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, 651 Dongfeng East Road, Guangzhou 510060, Guangdong, People's Republic of China.

Theranostics
|December 4, 2024
PubMed
概括

斯芬哥辛激酶1 (SPHK1) 通过抑制抗瘤免疫力,促进头癌的生长. SPHK1和MMP1预测对PD-1免疫疗法的反应,并作为治疗点.

关键词:
在HNSCC中,我们可以看到HNSCC.在MMP1中,MMP1是MMP1.在PD-1上.在PD-L1中.这就是SPHK1的原因.

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