氧化严重程度类别和长期生活质量,在儿童中幸存下来感染性休克
Joseph G Kohne1,2, Erin F Carlton1,2, Stephen M Gorga1
1Division of Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, United States.
与败血症相关的急性呼吸衰竭幸存下来的儿童面临着对其生活质量的风险. 所有的氧化衰竭类别,包括轻度,都与潜在的与健康有关的生活质量下降有关,需要全面的跟踪.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 呼吸衰竭研究 呼吸衰竭研究
- 生活质量研究 生命质量研究
背景情况:
- 与败血症相关的急性呼吸衰竭是儿童的危急状况.
- 氧化衰竭的严重程度在儿科患者中可能有很大差异.
- 与健康相关的生活质量 (HRQL) 是幸存者的关键结果衡量标准.
研究的目的:
- 确定早期氧化衰竭严重程度类别是否与儿科败血症幸存者的HRQL恶化相关.
- 评估缺席/轻度/中度/严重氧化衰竭与长期HRQL结果之间的关联.
- 为了确定HRQL在败血症后下降的风险因素.
主要方法:
- 儿科败血症后生命评估研究的二次分析.
- 包括291名儿童,他们幸存下来了儿科败血症休克和侵入性通风.
- 后勤回归模型用于分析氧化衰竭严重程度与HRQL下降 (≥25%在3,6,12个月) 之间的关联.
主要成果:
- 15%的儿童在3个月后HRQL下降≥25%.
- 在3,6或12个月后,氧化衰竭严重程度和HRQL下降之间没有发现显著的关联.
- 氧化不足与功能状态的下降有关,无论严重程度如何.
结论:
- 所有氧化不足类别的儿童在败血症后面临HRQL下降的风险.
- 轻微的肺损伤不应阻止儿童获得全面的随访护理.
- 需要进一步的研究来确定高风险患者的特定风险因素.
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