艾米试验:我们所知道的和我们需要知道的
Arvind Jaiswal1, Swati Chaurasia2, Akshyaya Pradhan3
1Department of Cardiology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Journal of family medicine and primary care
|December 4, 2024
概括
-葡萄糖共运输体-2 (SGLT-2) 抑制剂在急性心肌梗塞 (MI) 患者中显示出安全性,降低了NT-pro-BNP水平. 然而,在等待进一步的试验结果之前,MI后的普遍使用尚未得到证明.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 内部医学 内部医学
背景情况:
- 起初用于糖尿病的-葡萄糖共运输体-2 (SGLT-2) 抑制剂,提供心血管方面的好处,包括心力衰竭 (HF) 降低和保留排泄分数.
- 经过急性心肌梗塞 (MI) 的患者面临高风险的发展HF和复发事件.
- 以前的试验,如PARADISE MI,在这种情况下没有显示ARNI的益处.
研究的目的:
- 评估SGLT-2抑制剂在急性心肌梗塞 (MI) 后患者中的作用和安全性.
- 评估SGLT-2抑制剂对心脏生物标志物和心脏回声学参数后MI的影响.
主要方法:
- 在EMMY试验中,研究了SGLT-2抑制剂 (empagliflozin) 在超过450名急性后心脏病发作的患者中使用.
- 在26周评估了NT-pro-BNP水平和左心室心声学参数的变化.
主要成果:
- 与标准治疗相比,使用SGLT-2抑制剂导致NT-pro-BNP水平显著降低.
- 恩帕格利弗洛辛在左心室回声心脏学参数中显示出额外的改善.
- 该试验证实了SGLT-2抑制剂在后MI人群中的安全性,尽管它很小,随访时间很短,缺乏临床终点.
结论:
- SGLT-2 抑制剂对于急性心脏病发作后的患者来说是安全的,并且可以改善心脏生物标志物和功能.
- 目前的证据不支持在所有心脏病后患者中普遍使用SGLT-2抑制剂.
- 目前正在进行的试验将进一步澄清SGLT-2抑制剂在MI后HF管理中的作用.
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