探索自然衍生的向纳米传递疗法用于烧伤伤愈合,特别强调临床前结果
Abhranil Bhuyan1, Piyali Dey1, Himanshu Gogoi1
1Faculty of Pharmaceutical Science, Assam down town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati 781026, Assam, India.
Current drug delivery
|December 4, 2024
概括
来自植物的纳米配方在治疗烧伤方面表现有前途,为传统药物提供了更安全的替代品. 需要进一步的研究才能充分理解它们的机制和临床应用.
科学领域:
- 药理学和纳米技术的应用
- 伤口治愈研究研究 伤口治愈研究
- 自然产品化学 自然产品化学
背景情况:
- 植物生物活性物具有长期的治疗用途历史,为现代药物提供更安全的替代品.
- 烧伤是一个重大的全球健康挑战,死亡率很高.
- 纳米技术的进步使得能够开发出新的基于植物的纳米配方,以提高治疗效果.
研究的目的:
- 审查植物衍生纳米配方在烧伤治愈中的当前临床前应用.
- 探索纳米技术对自然产品对向烧伤治疗的影响.
- 总结关于草药纳米配方 (HBNF) 用于烧伤治疗的发现.
主要方法:
- 从1990年到2024年,对科学数据库 (PubMed,科学网,科学直播,谷歌学者) 的综合文献搜索.
- 包含和排除标准适用于大约180个获取的研究.
- 对40项关于植物提取物及其纳米配方用于临床前烧伤模型的研究进行查和分析.
主要成果:
- 确定了40种不同的植物及其纳米配方 (NFs),具有前临床烧伤愈合活性.
- 纳米输送系统调节生物活性化合物的有效性,并抑制灼伤伤口的炎症.
- 基于植物的纳米技术通过各种细胞机制展示了潜力.
结论:
- 草药纳米配方 (HBNF) 代表了自然衍生向治疗在烧伤管理中的有希望的途径.
- 纳米输送系统提高了天然产品的兼容性和有效性,用于伤口愈合.
- 需要进一步的临床研究来阐明作用机制,并验证人体模型中的疗效.
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