抗精神病药物和呼吸系统衰竭的风险在呼吸系统高度依赖的单位
Sara Winter1,2,3, Tara Kirkpatrick4, Karl Winckel4,5
1Faculty of Medicine, University of Queensland, Brisbane, Australia.
BJPsych open
|December 4, 2024
概括
抗精神病药物与进入呼吸高度依赖单位 (HDU) 的患者呼吸衰竭和再入院的风险增加有关. 建议对这些患者的抗精神病药物使用进行仔细审查.
科学领域:
- 肺部医学 肺部医学
- 精神病学是一个精神病学.
- 临床药理学 临床药理学
背景情况:
- 在呼吸系统高度依赖单位 (HDU) 中,严重精神疾病 (SMI) 和抗精神病药物的使用率高.
- 关于呼吸衰竭和抗精神病药物之间的关系的数据有限.
研究的目的:
- 在HDU患者中研究抗精神病使用与呼吸衰竭之间的关联.
- 了解抗精神病药对呼吸系统结果的影响.
主要方法:
- 追溯分析了638名接受呼吸道HDU治疗的患者.
- 收集的数据包括从2018年1月到2021年5月的医学,人口和临床结果.
主要成果:
- 抗精神病药物增加了2型呼吸衰竭 (3.7倍) 和COPD恶化的风险 (11.45倍).
- 使用抗精神病药物增加了4.9倍的非侵入性通风的风险,2型呼吸衰竭.
- 接受抗精神病药物的患者有更高的30天再入院率;超过30%是未经许可的指示.
结论:
- 呼吸系统不良的结果可能是抗精神病药物的不良药物反应.
- 优先优化慢性健康状况,为SMI患者处方抗精神病药物.
- 考虑对服用抗精神病药物的SMI患者的临床护理和治疗途径进行修改.
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